Bacterial Vaginosis: Reevaluating Transmission Mechanisms and Treatment Strategies
Bacterial vaginosis (BV) has primarily been seen as a condition arising from an imbalance of bacterial populations in the vagina, rather than as a sexually transmitted infection (STI). However, recent findings are prompting a reevaluation of this perspective.
Study Findings Shifting Perspectives
A study recently published in the New England Journal of Medicine suggests that BV might indeed be transmitted through sexual contact. The research indicates that treating male partners alongside women may be essential not only for curing both individuals but also for preventing reinfection.
Women suffering from BV often report symptoms such as discomfort and a distinctive “fishy” odor, which can be associated with severe health risks, including:
- Newborn complications
- Premature birth
- Infertility
- Increased susceptibility to STIs, including HIV
- Pelvic inflammatory disease
Standard treatment for BV involves a one-week course of oral antibiotics; however, over half of patients experience a recurrence within three months following treatment.
Research Methodology
The Australian study involved 164 monogamous couples, in which researchers analyzed the effects of simultaneous treatment. One group of couples received only the standard antibiotics for women, while the other group treated both partners. The latter group, which included men taking oral antibiotics and applying a topical treatment, showed promising results.
After a 12-week period, the recurrence rate of BV in women whose male partners were also treated was 35%, in contrast to 63% in women who were treated alone.
“This successful intervention is relatively cheap and short and has the potential for the first time to not only improve BV cure for women, but opens up exciting new opportunities for BV prevention, and prevention of the serious complications associated with BV,” stated Dr. Catriona Bradshaw, a co-author of the study.
The STI Debate
The study raises an important question: should BV be classified as an STI? Dr. Lenka Vodstrcil, another author of the research, commented on the similarities between BV and STIs, citing a comparable incubation period and common risk factors such as changes in sexual partners and lack of condom use.
Historically, evidence of sexual transmission was minimal, with past trials failing to demonstrate improved outcomes through male partner treatment. However, limitations in the study designs and treatment methods are now being reconsidered.
Current Understanding of BV
Despite the findings supporting the hypothesis of sexual transmission, Dr. Alessandra Hirsch, an expert in obstetrics and gynecology, cautions that not all instances of BV are related to sexual activity. Moreover, women may experience recurrent BV due to non-sexual factors, such as yeast infections.
“Categorizing BV as an STI may further stigmatize the condition,” she advises, highlighting the need to destigmatize STIs within the medical community.
Implications for Treatment Guidelines
Following the study’s insights, healthcare professionals at the Melbourne Sexual Health Centre have revised their guidelines to recommend simultaneous treatment for male partners of women diagnosed with BV in monogamous relationships. However, it remains uncertain when or if these guidelines will be adopted in the United States, where existing recommendations from organizations like the American College of Obstetricians and Gynecologists (ACOG) and the CDC may take time to evolve.
U.S. healthcare providers are still expected to utilize established medications, such as metronidazole or clindamycin gel, for treating BV in both partners.
References
Vodstrcil LA, Plummer EL, Fairley CK, et al. Male-partner treatment to prevent recurrence of bacterial vaginosis. N Engl J Med. 2025;392(10):947-957. doi:10.1056/NEJMoa2405404
Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1-187. doi:10.15585/mmwr.rr7004a1
Ravel J, Moreno I, Simón C. Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. Am J Obstet Gynecol. 2021;224(3):251-257. doi:10.1016/j.ajog.2020.10.019
Monash University. New STI impacts 1 in 3 women: landmark study reveals men are the missing link.